Rejuran Cream

Polynucleotides (PN) are long-chain DNA fragments derived from salmon sperm (polydeoxyribonucleotide, PDRN) or other purified sources. In injectable aesthetic medicine, REJURAN Healer (the injectable) is one of the most clinically validated PN treatments for skin regeneration - it stimulates fibroblasts, increases hyaluronic acid synthesis, and accelerates wound healing. The published clinical data on injectable PN is substantial and this is what gave REJURAN its reputation in Korean dermatology clinics before it launched topical products.

Topical PN in a cream cannot replicate injectable PN's direct dermal delivery - the cream concentration and skin penetration depth are lower. But topical PN still interacts with epidermal receptors involved in cell signaling, and accumulated daily delivery creates meaningful long-term skin improvement in collagen production, hydration, and surface renewal. This is the scientific basis for REJURAN's topical cream range.

The REJURAN Healing Cream 50ml is the base product in the topical range - the formula closest to a daily-use face cream built around the PN healing signal. It applies across most skin types and concerns as a twice-daily moisturizer that delivers PN actives alongside standard cream base emollients. At 50ml it is a standard Korean face cream size providing two to three months of daily use.

Use the Healing Cream after toner and essence in a routine, as the final moisturizer step before SPF (AM) or sleep (PM). The healing focus means it is particularly well-suited for skin recovering from breakouts, minor irritation, or environmental stress - the PN signals support the same cell repair mechanisms that the injectable version accelerates in clinical settings.

The Healer Nutritional Cream 50ml, Healer Nutritive Cream 50ml, and the Nutritional Cream 50ml are closely related products in the Healer sub-line, all adding nutritive (amino acid, peptide, vitamin) support to the PN base. The "Healer" prefix across these products signals they carry the highest PN concentration in the topical REJURAN range - the Healer line is REJURAN's premium cream tier. "Nutritional" and "Nutritive" are near-synonymous labels representing different batch or localization naming, likely the same formula.

These creams are the most intensive daily-use option in the lineup. They work best for mature skin (35+) or skin showing early loss of firmness, volume, or a dull, sallow appearance suggesting slowing cell renewal. Use in the PM routine when the PN and nutritive actives can work without UV exposure competition.

The Healer Turnover Active Cream 50ml, Healer Turnover Synergy Cream 45ml, and the Lejouran Healer Turnover Cream 50ml all center on accelerating skin cell turnover. Cell turnover is the process of new skin cells replacing old ones - it slows with age, resulting in duller complexion, uneven texture, and thicker dead skin layer. The Turnover formulas use PN alongside turnover-accelerating actives (likely AHAs, retinol-adjacent compounds, or cell-signaling peptides) to specifically target this slowdown.

Among the three, the Turnover Active emphasizes the activation phase, the Turnover Synergy combines multiple synergistic actives, and the Lejouran Turnover is positioned as a specific sub-brand variant. All are PM-appropriate creams given the turnover-active focus. For AM use, the Healing Cream or Hydrating Cream is less likely to cause photosensitivity than the Turnover formulas.

The REJURAN Advanced Hydrating Cream 50g shifts the focus from PN cell renewal to deep hydration. This is the most moisture-delivery-focused cream in the REJURAN range - suited for dehydrated skin where restoring water content is the primary concern before any collagen or renewal treatment. The advanced hydrating formula likely uses multiple molecular weights of hyaluronic acid, glycerin, or similar water-binding humectants alongside PN for a combined hydration-plus-signal approach.

Use the Advanced Hydrating Cream in situations where your skin is dehydrated: after travel, in low-humidity environments, during winter indoor heating season, or when other actives have compromised your barrier. It is a safe daily cream for most skin types and can be used AM and PM without turnover concerns.

The Dermahiller Moisture Cream 60g is the largest single cream unit in the REJURAN topical range and the formula positioned under the Dermahiller sub-brand. At 60g it offers slightly more product than the standard 50ml jars - roughly three to four months at once-daily full-face use. The Dermahiller name references the brand's emphasis on derma (skin) healing, consistent with REJURAN's clinical background. The Moisture Cream format provides sustained hydration alongside PN, sitting between the pure healing focus of the Healing Cream and the deep water delivery of the Advanced Hydrating Cream.

The 60g size makes this the most cost-effective per-gram cream in the REJURAN range, which matters for buyers who want to use REJURAN as their primary daily moisturizer on an ongoing basis rather than cycling it with other brands.

The REJURAN cream range divides into two tiers. The Healer line (Nutritional, Nutritive, Turnover Active, Turnover Synergy, Lejouran Turnover) uses a higher PN concentration and more intensive active support - these are the treatment-grade topical products closest to the brand's injectable heritage. The standard line (Healing Cream, Advanced Hydrating, Dermahiller Moisture) uses PN at a maintenance concentration in a more universally applicable base - these are the daily use and accessible entry-point creams.

Start with the Healing Cream or Advanced Hydrating Cream as a first REJURAN purchase. Confirm your skin tolerates the PN actives well over two to four weeks, then step up to the Healer Nutritional or Turnover creams for a more intensive treatment phase. For highly sensitive skin, the standard line is less likely to cause the rare irritation that concentrated actives can trigger.

All REJURAN topical creams go at the moisturizer step - after toner, after essence or serum, and before SPF (AM) or as the final PM step. A pea-sized amount covers the full face; the dense PN formula does not require a thick application layer to deliver its actives. In AM routines, the non-Turnover creams (Healing, Hydrating, Dermahiller) are the preferred choices as they have a lower photosensitivity profile than the Turnover-active formulas. In PM routines, any REJURAN cream is appropriate.

REJURAN creams are compatible with most toners, essences, and serums. If you use retinol or high-concentration AHA, apply REJURAN cream after the retinol or AHA step to provide a recovery buffer - the PN healing signals support barrier repair alongside the active treatment. This is a particularly effective combination because retinol and AHAs drive turnover while REJURAN PN supports the recovery from that accelerated turnover.