Natureclinic
NATURECLINIC is a Korean clinical skincare brand with 11+ high-concentration ampoules on skinsli, all at 10ppm in 10ml vials. The lineup includes growth factor ampoules (IGF, EGF, FGF), Retinol Vitamin A, Borphyrin, Idevenon, and a Jinsheng Stem Serum - ingredients typically found in dermatology clinic treatments, packaged for home or professional use.
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Buying guide
NATURECLINIC Ampoule Guide: Growth Factors, Retinol, and Clinical-Grade 10ppm Actives
NATURECLINIC is a Korean clinical skincare brand whose entire skinsli assortment consists of 10ml ampoules formulated at 10ppm - a concentration level associated with professional aesthetic treatments rather than standard over-the-counter skincare. The lineup covers growth factors (EGF, IGF, FGF), Retinol Vitamin A, Borphyrin, Idevenon, and a Jinsheng Stem Serum. This guide explains what each active does, who the ampoules are for, and how to use them safely.
What NATURECLINIC Is and Who It's For
NATURECLINIC bridges the gap between clinic-exclusive skincare and home use. Growth factor ampoules like EGF and FGF are common in Korean dermatology clinic protocols - applied as part of post-laser or post-microneedling treatments to accelerate skin repair. NATURECLINIC packages these at 10ppm in home-use 10ml vials, making the same active-ingredient category accessible without a clinic visit.
The brand is suited for experienced skincare users who understand how to introduce concentrated actives carefully, for people who have already used clinic-grade treatments and want to continue the benefit at home, and for anyone following a Korean skin-cycling or ampoule-layering protocol. The 10ml format is sized for single-active cycling rather than daily full-face application - using 2-3 drops per session, each bottle lasts several weeks.
EGF 10ppm Ampoule: Epidermal Growth Factor
The NATURECLINIC EGF 10ppm Ampoule is the most widely known product type in the lineup. EGF (Epidermal Growth Factor) is a peptide that binds to growth factor receptors in the skin, stimulating cell proliferation and skin renewal. It is associated with accelerated wound healing and skin recovery and is used post-procedure in Korean clinic skincare for post-laser, post-microneedling, and post-peel recovery.
At 10ppm, the NATURECLINIC EGF Ampoule delivers a clinically relevant concentration - lower concentrations in standard over-the-counter products (0.1-1ppm) typically produce slower, more diffuse results. Apply 2-3 drops to clean skin after toning and press gently. On post-treatment skin (after a home peel or microneedling session), EGF ampoules are most effective because the skin's barrier is temporarily permeable, increasing absorption.
IGF 10ppm: Insulin-Like Growth Factor
The NATURECLINIC IGF 10ppm Ampoule contains Insulin-Like Growth Factor (IGF-1 or its cosmetic equivalent), which plays a role in collagen synthesis stimulation and fibroblast activation in the skin. IGF-1 is a downstream mediator of growth hormone signaling and is associated with improved skin density and firmness over prolonged use. In Korean aesthetic medicine, IGF is used alongside EGF in skin booster injections and post-procedure protocols.
In a home ampoule routine, IGF can be alternated with EGF (EGF one evening, IGF the next) or layered in the same session for combined growth factor coverage. Start with one active at a time when introducing growth factor ampoules for the first time, allowing the skin to adjust before adding a second.
FGF 10ppm: Fibroblast Growth Factor
The FGF (Fibroblast Growth Factor) 10ppm Ampoule stimulates fibroblast cells - the skin cells responsible for producing collagen and elastin. FGF is one of the most studied growth factors in dermatology for its role in wound healing and tissue repair. In cosmetic application, it is associated with improvement in skin texture, fine lines, and skin thickness when used consistently over weeks to months.
Of the three growth factors in the NATURECLINIC range (EGF, IGF, FGF), FGF is most directly associated with collagen production support. For anti-aging protocols focused on firmness and density, FGF is the primary active to incorporate. It can be rotated with EGF and IGF on an alternating schedule or used as the sole growth factor ampoule depending on the user's focus.
Retinol Vitamin A 10ppm Ampoule
The NATURECLINIC Retinol Vitamin A 10ppm Ampoule is a pure retinol concentrate - 10ppm retinol is a significant concentration for a topical ampoule. Retinol (Vitamin A) is the most clinically validated anti-aging active in over-the-counter skincare, associated with accelerated cell turnover, collagen synthesis, and reduction in fine lines, wrinkles, and pigmentation over 12+ weeks of consistent use.
Retinol at high concentrations causes purging (temporary skin worsening), dryness, and sensitivity in the initial weeks of use. Start with once or twice per week application of 1-2 drops on evenings when you are not using other actives, gradually increasing frequency as tolerance builds. Do not combine with the EGF/IGF/FGF growth factor ampoules on the same evening during initial use, as stacking concentrated actives increases irritation risk.
Borphyrin Ampoule: Multi-Pack Sizes and Porphyrin Chemistry
The NATURECLINIC Borphyrin Ampoule (available in 1, 2, 3, and 4 ampoule packs, each at 10ml) is a porphyrin-based active - porphyrins in skincare are typically used for sebum regulation, pore minimizing, and acne-control applications. Porphyrin compounds have photoactive properties that are used in some clinic-grade acne treatments. In the NATURECLINIC cosmetic context, the Borphyrin Ampoule is positioned for pore care and skin clarity.
The multi-pack options (1 through 4 ampoules) provide a built-in scale from a one-session trial to a monthly treatment course. The single 10ml ampoule is a 2-4 week supply at 2-3 drops per application; four ampoules gives approximately 8-16 weeks of treatment. Use the Borphyrin Ampoule as a standalone acne or pore-focus step, applied to clean skin after toning in the evening on non-retinol, non-growth-factor nights.
Idevenon Ampoule and Jinsheng Stem Serum
The Idevenon Ampoule (10ml, 10ppm) contains Idebenone - a synthetic analogue of CoQ10 (coenzyme Q10) with stronger antioxidant activity. Idebenone is associated with protection against oxidative stress from UV and pollution, and with improvement in skin texture and fine lines when used consistently. It is positioned as an antioxidant treatment ampoule in the NATURECLINIC range, suitable for environmental protection-focused routines.
The Jinsheng Stem Serum (10ml) uses plant stem cell extracts - typically derived from Swiss apple, rose, or argan plant stem cells in Korean stem serum formulations - for anti-aging and skin regeneration support. Stem cell extracts in cosmetics are not living cells and do not divide in the skin; they provide growth factor-like signaling molecules and phytonutrients that support the skin's own renewal cycle. The Jinsheng Stem Serum can be layered after the growth factor ampoules or used independently as a regenerative evening treatment.
How to Rotate NATURECLINIC Ampoules Safely
With 7+ different clinical actives in the NATURECLINIC range, a rotation schedule prevents stacking too many concentrated treatments on the same evening while maximizing the benefit of each active over a week. A practical starting rotation for an experienced user: Monday - EGF; Tuesday - Retinol; Wednesday - Borphyrin; Thursday - FGF; Friday - IGF; Saturday - Idevenon or Jinsheng Stem Serum; Sunday - rest/barrier recovery with a simple moisturizer and no active ampoule.
For a user new to growth factor ampoules, start with just one active (EGF or Retinol) for the first two weeks, adding one more active per week as the skin tolerates. Do not introduce all 7 actives simultaneously - the skin needs time to adjust to each new clinical-concentration ingredient before layering additional ones.
FAQ
Frequently asked questions
FAQ
Frequently asked questions
What does the NATURECLINIC EGF 10ppm Ampoule do for the skin?
EGF (Epidermal Growth Factor) is a peptide that stimulates skin cell renewal and repair by binding to growth factor receptors in the skin. At 10ppm concentration, the NATURECLINIC EGF Ampoule accelerates skin recovery after procedures (laser, microneedling, peels) and supports ongoing cell turnover for anti-aging benefit. Visible results from growth factor ampoules - improved texture, reduced fine lines, more even tone - typically appear after 4-8 weeks of consistent use.
What is the difference between EGF, IGF, and FGF in the NATURECLINIC lineup?
EGF (Epidermal Growth Factor) stimulates cell proliferation and skin renewal - primary use is post-procedure recovery and cell turnover support. IGF (Insulin-Like Growth Factor) is associated with collagen synthesis and fibroblast stimulation - it works on skin density and firmness. FGF (Fibroblast Growth Factor) directly stimulates fibroblast cells, which produce collagen and elastin - most directly linked to anti-aging firmness improvement. All three are at 10ppm in 10ml vials. They can be rotated on different evenings for comprehensive growth factor coverage rather than using all three on the same night.
How often should I start using the NATURECLINIC Retinol Vitamin A 10ppm Ampoule?
Start with once per week application for the first 2 weeks, then increase to twice per week for 2 more weeks, then 3 times per week if the skin tolerates well (no sustained redness, peeling, or irritation). A 10ppm retinol concentration is significant - most beginners experience a temporary purging period (skin worsening before improving) in the first 4-6 weeks. Apply 1-2 drops in the evening only, not in the morning (retinol degrades with UV exposure and can increase photosensitivity). Always follow with a moisturizer and apply sunscreen the next morning.
Is the NATURECLINIC Borphyrin Ampoule suitable for active acne?
The Borphyrin Ampoule is formulated for pore care, sebum regulation, and skin clarity - which includes support for acne-prone skin. Porphyrin-based actives in clinic protocols are used for their photoactive sebum-regulating properties. For active acne, the Borphyrin Ampoule can be used as a targeted treatment step on acne-prone zones (2-3 drops applied to the T-zone or cheeks), but it is not a spot treatment substitute for a dedicated anti-acne ingredient like salicylic acid or benzoyl peroxide. It is best used as a preventive and pore-management step in an ongoing routine.
How does the NATURECLINIC Idevenon Ampoule compare to a vitamin C serum as an antioxidant?
Idebenone (in the NATURECLINIC Idevenon Ampoule) is a synthetic CoQ10 analogue with stronger and more stable antioxidant activity than pure vitamin C. Unlike vitamin C, which degrades quickly after oxidation and requires refrigerated storage, idebenone is chemically stable and maintains activity throughout the bottle's shelf life. Idebenone is particularly effective at protecting against pollution-induced oxidative stress. For someone who finds vitamin C serums unstable, irritating, or ineffective, idebenone is a functional alternative for the antioxidant step.
Should I buy 1, 2, 3, or 4 NATURECLINIC Borphyrin Ampoules?
Start with 1 ampoule (10ml) to confirm the formula suits your skin before committing to multiple vials. One 10ml ampoule gives approximately 2-4 weeks of treatment at 2-3 drops per session, 3-4 times per week. If you plan to use the Borphyrin Ampoule as a regular monthly active, the 4-ampoule pack covers 2-4 months of supply at a lower per-ampoule cost. The 2 and 3-ampoule packs are intermediate options for users who have confirmed the formula but are not yet ready for the full 4-pack commitment.
Can I use the NATURECLINIC Jinsheng Stem Serum on the same night as a growth factor ampoule?
Yes. The Jinsheng Stem Serum (10ml) uses plant stem cell extracts that are complementary rather than competing with growth factor ampoules. Apply the growth factor ampoule (EGF, IGF, or FGF) first - 2-3 drops pressed into clean, toned skin - wait 30-60 seconds, then apply the Stem Serum. The stem serum provides phytonutrient support for the skin's own regeneration cycle and does not interfere with the growth factor binding process. This combination is a strong anti-aging treatment session.
How many NATURECLINIC products are available on skinsli?
There are 11+ NATURECLINIC products currently in stock on skinsli: EGF 10ppm Ampoule, IGF 10ppm Ampoule, FGF 10ppm Ampoule, Retinol Vitamin A 10ppm Ampoule, Idevenon Ampoule, Borphyrin Ampoule in 1/2/3/4-vial packs, and Jinsheng Stem Serum - all in 10ml vials.
Can I use the NATURECLINIC Retinol and EGF ampoules on the same evening?
Not recommended during the initial introduction phase of either active. High-concentration retinol temporarily makes the skin barrier more permeable and can amplify the intensity of other actives, increasing irritation risk. Once you have used each ampoule individually for several weeks and the skin has built tolerance for both, some experienced users combine them at reduced doses (1 drop each). If you have sensitive or reactive skin, keep them on separate evenings permanently. The safest protocol is to alternate: Retinol on one evening, EGF on the next.