MEDIPEEL Peptides
MEDIPEEL's peptide collection spans 36+ products built around the brand's two peptide platform lines: Peptide 9 and Bortox/Toxbor. The Peptide 9 range covers a complete skincare routine - Essence Toner (250ml), Essence Emulsion (250ml), Volume Essence (100ml), and even targeted formats like Melastick (10g), Biosunstick (20g), and Melasticide Multivam (10g) for stick-form treatment. The Bortox Peptide Cream (50ml) and Peptide Toxbor Cream (50g) bring the botulinum-peptide approach to the moisturizer step, and the Peptide Toxbor Eye Cream (40ml) covers the orbital area. MEDIPEEL's peptide products are among their most recognizable for addressing anti-aging concerns at the routine foundation level.
By Skinsli editorial Updated
Buying guide
MEDIPEEL Peptide Collection: Peptide 9 and Bortox Lines Explained
MEDIPEEL's peptide collection is organized around two main product families: Peptide 9 (a numbered-peptide complex that covers toner through targeted stick formats) and Bortox/Toxbor (botulinum-peptide-focused creams and eye cream). With 36+ products, the collection offers one of the most complete single-brand peptide routine options in Korean skincare. This guide covers each product line, the peptide types involved, and how to build a routine from the collection.
What Peptides Do in Skincare
Peptides are short chains of amino acids - smaller fragments of proteins - that act as signaling molecules in the skin. Different peptide types target different mechanisms: signal peptides trigger collagen and elastin synthesis, carrier peptides deliver trace metals needed for enzyme function, neurotransmitter-inhibiting peptides (like Argireline) reduce muscle contraction at expression lines, and enzyme-inhibiting peptides slow down collagen breakdown. MEDIPEEL uses combinations of these across their Peptide 9 and Bortox/Toxbor products.
The "9" in Peptide 9 refers to a 9-peptide complex that combines multiple types simultaneously - the logic being that different peptide mechanisms working together produce better results than any single peptide alone. This approach is consistent with current dermatological thinking on peptide cocktails.
Peptide 9 Toner and Emulsion: Routine Foundation
The Peptide 9 Essence Toner (250ml) and Peptide 9 Essence Emulsion (250ml) form the base layer of the Peptide 9 routine. Both large-format products are designed for daily morning and evening use across multiple months. The Essence Toner applies after cleansing and delivers the 9-peptide complex in a hydrating toner base that prepares the skin for subsequent product absorption. The Essence Emulsion is a lightweight moisturizing layer that sits between toner and a heavier cream, again delivering the peptide complex at this second routine step.
Using both in the same routine doubles the peptide contact window before the final serum and moisturizer steps. The large 250ml size of each makes building a daily Peptide 9 routine feasible without running out quickly.
Peptide 9 Volume Essence: The Serum Step
The Peptide 9 Volume Essence (100ml) is the treatment serum in the line. At 100ml, it is unusually large for a peptide essence - most comparable products come in 30-50ml formats. The "Volume" name targets skin density and plumpness, with the peptide complex working alongside volumizing actives (hyaluronic acid-adjacent and ceramide-type) to fill in areas of reduced skin fullness. Apply after the Peptide 9 Toner and before the Emulsion or a cream.
The Volume Essence works particularly well for skin showing early loss of the plump, bouncy quality associated with youthful skin density. It adds volume-restoring treatment at the highest active concentration point in the Peptide 9 routine, with the toner and emulsion providing supporting lower-concentration peptide delivery at the flanking routine steps.
Bortox Peptide Cream and Toxbor Cream: Neurotransmitter Peptides
The Bortox Peptide Cream (50ml) and Peptide Toxbor Cream (50g) both use MEDIPEEL's botulinum-adjacent peptide approach as the moisturizer step. The naming Bortox and Toxbor are variations on the Botox concept adapted to topical peptide form. Both creams use Argireline (acetyl hexapeptide-3) and similar muscle-relaxing signal peptides alongside standard moisturizing actives, targeting expression lines around the forehead, eyes, and mouth with consistent daily application.
The 50ml/50g sizes provide 2-3 months of daily use. The Bortox Peptide Cream and Peptide Toxbor Cream are formulation variants of the same concept - one may use slightly different peptide ratios or base textures. Using either as your morning and evening moisturizer positions the muscle-relaxing peptide as a daily foundation rather than an occasional treatment.
Peptide Toxbor Eye Cream 40ml: Orbital Area Treatment
The Peptide Toxbor Eye Cream (40ml) applies the Toxbor muscle-relaxing peptide to the eye area specifically - the zone most affected by expression-related fine lines (crow's feet, under-eye creasing from squinting). At 40ml, it is notably larger than most Korean eye creams, which typically come in 15-25ml formats. The size allows more generous application and more complete coverage of the orbital zone than a small-format eye cream encourages.
Apply after the Peptide 9 Toner or Emulsion and before the face cream. Use the ring finger to pat a small amount around the orbital bone from the inner corner outward, both morning and evening. The muscle-relaxing peptide effect in the eye area is the most visible with this cream because crow's feet and fine lines are direct expressions of repeated muscle movement - the peptide actively reduces the contraction frequency and depth over daily use.
Melastick, Biosunstick, and Melasticide: Stick-Format Peptide Products
Three products in this collection come in a stick format: Peptide 9 Melastick (10g), Peptide 9 Biosunstick (20g), and Peptide 9 Melasticide Multivam (10g). Stick-format skincare is a format innovation in Korean skincare that allows targeted, mess-free application to specific zones. The Melastick is a targeted skin treatment in stick form. The Biosunstick is an SPF product in stick form - practical for reapplying SPF over makeup midday without disturbing base. The Melasticide Multivam adds a multi-vitamin component to the stick treatment.
These stick products extend the Peptide 9 range into formats suited for on-the-go use, spot treatment, and SPF reapplication - use cases where tubes and bottles are impractical. The 10-20g sizes are compact by design.
Building a Peptide 9 + Bortox Routine
A complete MEDIPEEL peptide routine using this collection: Morning - Peptide 9 Essence Toner - Peptide 9 Volume Essence - Peptide 9 Essence Emulsion - Bortox Peptide Cream or Peptide Toxbor Cream - Peptide 9 Biosunstick for SPF touch-up midday. Evening - Peptide 9 Essence Toner - Peptide 9 Volume Essence - Peptide 9 Essence Emulsion - Peptide Toxbor Cream - Peptide Toxbor Eye Cream at the eye area.
This is a full peptide-saturated routine where every step delivers some quantity of the peptide complex. The logic is cumulative: more contact time and more application windows per day result in higher total peptide exposure, which produces faster results than using a single peptide product in isolation. For a minimal version, the Peptide 9 Volume Essence and either the Bortox or Toxbor cream form a two-product effective core.
Combining MEDIPEEL Peptides with Retinol
Peptides and retinol are sometimes cited as incompatible due to pH considerations (AHAs can degrade some peptides), but peptide serums and retinol are generally compatible when not used simultaneously in the same step. Apply the Peptide 9 Volume Essence at a separate step from retinol - either morning peptide and evening retinol, or apply the peptide essence first and allow it to absorb before applying retinol. The muscle-relaxing Bortox/Toxbor creams can be used as the moisturizer step after retinol without conflict.
The combination of retinol (collagen gene expression stimulation) and signal peptides (direct collagen synthesis signaling) is actually synergistic - both mechanisms promote new collagen through different pathways. Many advanced anti-aging routines intentionally combine retinol with a multi-peptide product for this reason.
FAQ
Frequently asked questions
FAQ
Frequently asked questions
What are the 9 peptides in the MEDIPEEL Peptide 9 complex?
The specific 9-peptide lineup varies by product in the Peptide 9 range, but the complex typically includes: signal peptides (palmitoyl tripeptide, palmitoyl tetrapeptide) for collagen and elastin synthesis, neurotransmitter-inhibiting peptides (Argireline/acetyl hexapeptide) for expression line relaxation, copper-carrier peptides for enzyme function, and enzyme-inhibiting peptides that slow collagen breakdown. The "9" combination is intended to hit multiple anti-aging mechanisms simultaneously rather than relying on a single peptide pathway.
What is the difference between the Bortox Peptide Cream and the Peptide Toxbor Cream?
Both use MEDIPEEL's botulinum-adjacent peptide complex in a cream base. The Bortox Peptide Cream is 50ml and may have a lighter cream texture suited for normal-to-oily skin. The Peptide Toxbor Cream at 50g is typically a slightly richer formula. The peptide mechanisms are functionally similar in both; the choice depends on skin type and texture preference. For combination or oily skin, Bortox Peptide Cream is generally the better fit. For dry or mature skin, the richer Toxbor Cream.
How do I use the Peptide 9 Biosunstick for SPF reapplication?
Swipe the Biosunstick directly across your face in light strokes, then lightly pat with your fingertip or a blotting paper to blend. For use over makeup, apply in a light layer and pat gently rather than rubbing to avoid disturbing foundation. The stick format deposits SPF without the spray mist that can disturb eye makeup, making it practical for midday reapplication at a desk or outdoors. The 20g stick lasts roughly 1-2 months of daily midday reapplication.
Should I use the Peptide 9 Volume Essence or the Peptide 9 Essence Toner as my serum?
The Volume Essence is the concentrated serum step, applied after the Essence Toner. The Essence Toner is a toner-texture product that prepares the skin and delivers a lighter first peptide dose; it is not a serum substitute. Use the Essence Toner first, then the Volume Essence for the concentrated treatment. Using the Essence Toner alone without the Volume Essence gives lower peptide exposure. The Volume Essence is the product that actually performs the targeted anti-aging work in the Peptide 9 routine.
Does the Peptide Toxbor Eye Cream reduce under-eye puffiness?
The muscle-relaxing peptides in the Toxbor Eye Cream target fine lines rather than puffiness directly. Puffiness has different causes (fluid retention, fat pad herniation, lymphatic flow) that peptide actives do not address effectively. For fine lines and crow's feet, the Toxbor Eye Cream is well suited. For puffiness, caffeine-containing eye creams or cooling eye patches are more relevant. The Toxbor Eye Cream can be used alongside a puffiness-targeting eye cream by applying one around the orbital area and the other directly under the eye.
How quickly do MEDIPEEL peptide products show results?
Surface improvements - plumper skin, smoother texture - can appear within 2-4 weeks of consistent use. Fine line softening from the neurotransmitter peptides typically becomes visible after 4-6 weeks of twice-daily use. Collagen density improvements take longer: 8-12 weeks of consistent application. Results are cumulative; skipping days delays the timeline proportionally. The full Peptide 9 routine covering multiple application steps per day shows faster results than a single-product approach.
What does the Peptide 9 Melasticide Multivam Stick do?
The Melasticide Multivam is a multi-vitamin treatment stick from the Peptide 9 line. The "Multivam" component combines multiple vitamins (typically vitamin C, B3, and related derivatives) with the peptide base for brightening and antioxidant delivery in stick format. It is a targeted application product for spot brightening or for convenient daily vitamin-peptide treatment on specific areas like the forehead, cheekbones, or areas with early pigmentation. The 10g size makes it a portable complementary product to the rest of the Peptide 9 range.
At what age should I start using MEDIPEEL peptide products?
Peptide products are appropriate from the mid-20s as prevention, and become increasingly relevant through the 30s and 40s as early anti-aging signs appear. There is no minimum age - the signal peptides that support collagen synthesis are beneficial for skin maintenance at any adult age. However, for people under 25 with no visible aging signs, the primary benefit is preventative rather than corrective. The neurotransmitter peptides in the Bortox/Toxbor line specifically benefit skin from around 28-30 when expression lines start becoming more persistent.
Are MEDIPEEL peptide products on skinsli.com authentic Korean imports?
Yes. All MEDIPEEL products on skinsli.com are sourced from Korean suppliers and carry Korean batch codes and expiry dates. Skinsli imports through verified channels and the products match the formulas sold in the Korean domestic market. MEDIPEEL's peptide product lines are well established Korean skincare items with documented active ingredient profiles.
Is the Peptide 9 Essence Toner at 250ml good value compared to smaller-format peptide toners?
Yes. At 250ml, the Peptide 9 Essence Toner provides approximately 4-6 months of daily twice-use at a standard 5-7ml per application. Most Korean skincare toners come in 150-200ml at similar or higher prices, making the 250ml Peptide 9 format notably cost-efficient. The larger format also removes the incentive to ration use, which means consistent application that drives better cumulative results.