Medipeel Derma

MEDIPEEL's Derma collection covers 5 products from two Derma-positioned lines: the Derma Maison range (Liposome Capsule Treatment 150ml, Time Wrinkle Collagen Volume Ampoule 100ml, Double Action Deep Tox Cleanser 200ml) and the Este Derma line (Lactobacillus Collagen Cleansing Foam 300ml). The Derma Maison products use liposomal encapsulation technology for deeper active delivery, while the Este Derma Foam combines lactobacillus ferment with collagen for a treatment-cleanser. These products are designed for skin that wants clinic-adjacent performance from at-home skincare.

  • Liposome Technology
  • Wrinkle Collagen Ampoule
  • Deep Detox Cleanser
  • Korean Clinical Brand

By Skinsli editorial Updated

Buying guide

MEDIPEEL Derma Products: Maison and Este Derma Explained

MEDIPEEL's Derma collection covers two sub-lines: Derma Maison (liposome-encapsulated formulas for deeper active delivery) and the Este Derma range (lactobacillus collagen formulas for cleansing). With 5 products spanning cleansers, a liposome treatment, and a large-format ampoule, this collection suits people who want effective anti-aging and deep-cleansing skincare with clinical-level delivery technology.

Liposome Encapsulation in Derma Maison

Liposome encapsulation is a delivery technology used extensively in clinical skincare and pharmaceutical topicals. A liposome is a tiny lipid-based sphere that wraps an active ingredient, protecting it until it reaches the skin's deeper layers. Because liposomes are made from phospholipids similar to cell membranes, they merge with skin cell membranes and release their payload inside the cell rather than sitting on the surface.

The Derma Maison Liposome Capsule Treatment uses this mechanism to deliver actives to deeper layers than standard topical formulas reach. The 150ml size is generous for a liposome treatment product, which typically comes in smaller formats due to the cost of the encapsulation technology. This size provides several months of daily use.

Derma Maison Liposome Capsule Treatment 150ml

The Liposome Capsule Treatment (150ml) is a leave-on treatment that delivers encapsulated actives through the liposome mechanism. The large 150ml format makes it practical for regular application across face and neck rather than conservative use as a spot-treatment. The capsule texture - typically a light cream or emulsion with visible micro-capsules - releases on skin contact as you spread the product.

This product sits at the serum or ampoule step in the routine. Apply after toner and before a heavier cream or moisturizer. The liposome technology means you do not need to use a large amount per application - the delivery mechanism works at lower concentrations than standard topicals, so using more does not proportionally increase results.

Time Wrinkle Collagen Volume Ampoule 100ml

The Derma Maison Time Wrinkle Collagen Volume Ampoule (100ml) is an anti-aging ampoule targeting fine lines, volume loss, and skin density using collagen peptides and volume-restoring actives. At 100ml, it is unusually large for an ampoule - most comparable products come in 30-50ml formats. This size reflects either a lower-than-typical concentration (requiring more product per use) or a product designed for multiple application layers or full-face and neck coverage with generous amounts.

The Time Wrinkle name focuses on age-related skin changes: fine lines, loss of fullness, and reduced skin spring. Collagen volume ampoules address these by delivering peptides that signal the skin's own collagen production and by providing surface-filling actives that temporarily plump fine lines from the outside. For visible wrinkle reduction, consistent daily use over 8-12 weeks is necessary.

Double Action Deep Tox Cleanser 200ml

The Derma Maison Double Action Deep Tox Cleanser (200ml) is a specialized cleanser with a "detox" positioning. Double-action cleansers typically combine two cleansing mechanisms - often a surfactant base and an oil or clay component - to remove both water-soluble and oil-soluble impurities more thoroughly than a single-action cleanser. The "Tox" suffix in Korean skincare often refers to deep-pore cleansing or detoxifying actives like charcoal, clay, or other adsorbent ingredients.

At 200ml, the Deep Tox Cleanser is a full-size format suitable as a primary evening cleanser for removing sunscreen and daily pollution accumulation. It can function as a standalone cleanser for people who do not need a full double-cleanse with an oil first, particularly on days without heavy makeup.

Este Derma Lactobacillus Collagen Cleansing Foam 300ml

The Este Derma Lactobacillus Collagen Cleansing Foam (300ml) bridges MEDIPEEL's Red Lacto Collagen DNA with the Derma product positioning. It combines lactobacillus ferment and collagen actives in a foaming cleanser format. Like the Derma Maison cleansers, it is positioned for skincare-active cleansing rather than pure makeup removal, with the lacto ferment providing mild chemical exfoliation alongside the foam's cleansing.

The 300ml format is large enough for morning and evening use over several months. This foam works well as the second step in a double-cleanse routine (after an oil-based first cleanser) or as a standalone morning cleanser when the skin does not carry heavy overnight product accumulation. The lactobacillus component makes it more appropriate for normal-to-oily skin; for dry skin, the lacto exfoliation may be slightly drying with daily use.

Building a Routine with the Derma Maison Line

A simple Derma Maison morning routine: Este Derma Lactobacillus Foam or Double Action Deep Tox Cleanser, followed by any toner, then the Liposome Capsule Treatment, followed by moisturizer and SPF. Evening: Double Tox Cleanser, toner, Time Wrinkle Collagen Volume Ampoule, and moisturizer. The Liposome Treatment can be layered before the ampoule (applying smaller molecules first and heavier textures later) or used as the sole treatment step in the morning when a lighter routine is preferred.

The Time Wrinkle Ampoule is better reserved for evening use when skin is in repair mode overnight. The Liposome Capsule Treatment works equally well morning or evening. This split keeps the more intensive regenerative formula active during sleep while the morning routine focuses on protection and treatment prep.

Who the MEDIPEEL Derma Collection Suits

The Derma collection is best for adults who are beginning to address anti-aging concerns - early fine lines, slight volume loss, and skin that looks less plump than it did a few years ago. The liposome technology and collagen ampoule approach are among the more technically advanced over-the-counter solutions in the Korean market. They do not require any prescription-level actives and are appropriate without clinical supervision.

People already using retinol or strong acids in their routine can layer Derma Maison products as supporting actives. The Liposome Capsule Treatment complements retinol by improving barrier function between treatment nights. The Time Wrinkle Ampoule provides collagen support that is synergistic with retinol's collagen-induction mechanism. The cleanser options are independent of the serum-level actives and can be used by any skin type.

FAQ

Frequently asked questions

  • Apply 2-3 pumps to clean, toned skin and gently spread across the face and neck. The capsules release on contact with skin warmth and mild spreading pressure. Do not rub aggressively - the micro-capsules need only light pressure to burst. Follow with moisturizer or the Time Wrinkle Ampoule. You can use it morning and evening, though once daily is sufficient for most people.

  • Surface smoothness and a plumper appearance from the collagen actives can appear within 2-3 weeks of daily use. Visible reduction in fine lines and improved skin density typically take 8-12 weeks of consistent twice-daily application. The ampoule works through collagen peptide stimulation, which is a slower mechanism than surface-filling formulas but produces more durable results with continuous use.

  • Yes. The 200ml format and its positioning as a daily cleanser support daily morning and evening use. Deep detox cleansers are sometimes gentler than the name implies - the "tox" refers to thorough removal of impurities rather than an aggressive formula. If you notice the cleanser leaving your skin feeling stripped or tight, reduce to once-daily evening use and use a gentler morning cleanse. Most normal-to-oily skin types tolerate it twice daily without dryness.

  • Liposome encapsulation can increase the delivery of some actives to deeper skin layers compared to standard topical formulas. The benefit depends on which actives are encapsulated. For lipid-soluble actives like retinol, vitamin E, and certain peptides, liposome delivery meaningfully improves skin-layer reach. For water-soluble actives, the difference is less pronounced. The Derma Maison Liposome Treatment is more efficient per gram of active ingredient than a standard serum, which is why the 150ml size provides extended use without proportionally high cost.

  • The lactobacillus ferment provides mild exfoliation alongside cleansing, which can be slightly drying for very dry or dehydrated skin with daily use. For dry skin, use the Este Derma Foam as an evening cleanser only and a gentler non-foaming cleanser in the morning. Normal and oily skin types can use it twice daily without the same dryness risk. Follow with toner immediately after cleansing to restore surface moisture.

  • Yes. Collagen peptide ampoules and retinol work synergistically - retinol stimulates collagen production through gene expression, while the collagen peptides provide direct peptide signals for synthesis. They do not interfere with each other. Apply the ampoule before retinol (thinner texture first) or alternate them morning and evening. The combination can accelerate anti-aging results compared to using either product alone.

  • Yes. All MEDIPEEL products on skinsli.com are sourced from verified Korean suppliers and match the formulas sold in the Korean domestic market. They carry Korean packaging with accurate batch codes and expiry dates. Skinsli does not distribute through grey-market channels.

  • With once-daily application of 2-3 pumps, a 150ml bottle typically lasts 3-5 months. Because liposome technology works at relatively low application volumes, you should not feel the need to use more than the recommended amount. Using more product does not increase the delivery efficiency of the liposome mechanism, so the 150ml stretches further than a standard serum of the same size.

  • The Time Wrinkle Collagen Volume Ampoule addresses concerns typically appearing in the late 20s to 30s and beyond: early fine lines, slight hollowing around the eyes, and reduced skin plumpness. It is appropriate as a preventative from the late 20s and increasingly relevant through the 30s and 40s. There is no minimum age requirement - if your concern is early wrinkle prevention, the ampoule is suitable regardless of age.

  • The double-action formula is more thorough than a single surfactant cleanser, but waterproof makeup formulas typically require an oil-based first cleanser to fully break down the film. For days with waterproof mascara or long-wear foundation, use a cleansing oil or balm first, then follow with the Deep Tox Cleanser as the second cleanse. Without the oil step, the Deep Tox Cleanser may remove light to moderate makeup but leave traces of waterproof formulas.