MEDIPEEL Ampoules
MEDIPEEL's ampoule collection brings together 27+ concentrated leave-on treatment ampoules spanning multiple active categories. The range includes brightening and pigmentation treatments (Melanone X Vitamin Ampoule 50ml, Mela Plus Tox Ampoule 30ml and 35ml), plant-detox formulas (Leaftox Ampoule 35ml, Celltox Dermage Ampoule 100ml), collagen and firming actives (Redracto Collagen Ampoule 70ml, Peptitox Ampoules), a floral ampoule (Royal Rose Premium Ampoule 100ml), a complementary cleanser (Melanone X Ampoule Cleanser 150ml), and the Hyaluronic Vita Toning Ampoule Mask. This is MEDIPEEL's most varied product category, covering nearly every skin concern in a single collection.
By Skinsli editorial Updated
Buying guide
MEDIPEEL Ampoules: Active Ingredient Guide
MEDIPEEL's ampoule lineup is the brand's widest product format, covering brightening, detox, collagen, peptide, hydration, and rose-based formulas across 27+ products. Each ampoule is a concentrated leave-on treatment applied after toner in the routine. This guide maps the major ampoule families, explains the key actives, and helps you choose based on your primary skin concern.
Tox Ampoule Family: Detox-Focused Formulas
MEDIPEEL uses the "Tox" suffix across several ampoules to indicate a detoxifying or cellular-cleansing mechanism. The Leaftox Ampoule (35ml) uses plant-based detox actives for a botanical approach. The Celltox Dermage Ampoule (100ml) - a notably large-format ampoule - uses cellular-level detox actives that address skin damage from oxidative stress and environmental exposure. The Peptitox Ampoules combine peptide actives with a toxin-neutralizing mechanism, often using a botulinum-adjacent peptide (Argireline-type) that relaxes facial muscle tension contributing to expression lines.
The Tox naming in Korean skincare is a direct reference to the Botox aesthetic concept, adapted into at-home topical form. The actives involved are not the same as injected botulinum toxin but use peptide analogues that aim for partial muscle-relaxing and wrinkle-softening effects applied topically over consistent use.
Melanone X and Mela Plus Tox: Brightening Ampoules
The brightening-focused ampoules in this collection are the Melanone X Vitamin Ampoule (50ml), Mela Plus Tox Ampoule (available in 30ml and 35ml sizes), and the Melanone X Ampoule Cleanser (150ml). Melanone X is MEDIPEEL's brightening sub-brand, targeting melanin production through multiple pathways: tyrosinase inhibition, melanin transfer blocking, and antioxidant protection against UV-induced pigmentation.
The Mela Plus Tox Ampoule combines brightening actives with a Tox mechanism, addressing both surface pigmentation and the muscle tension component that can affect skin unevenness. The two size options (30ml and 35ml) reflect slightly different formula concentrations or use patterns - the 35ml is typically the standard retail size for this product, while the 30ml is a slightly more concentrated version.
Redracto Collagen Ampoule 70ml: Lacto-Collagen Bridge
The Redracto Collagen Ampoule (70ml) sits at the intersection of the Red Lacto Collagen line and the standalone ampoule category. The lactobacillus ferment component provides mild exfoliation and microbiome-supportive delivery alongside the collagen peptides. At 70ml, it is larger than typical treatment ampoules, making daily twice-use practical over a longer period without running out.
This ampoule suits people who want the Red Lacto Collagen formula benefits in a standalone ampoule format without building the full routine. It pairs well with any standard cleanser and toner, providing the line's key collagen and lacto actives as a single serum step.
Royal Rose Premium Ampoule 100ml: Floral Actives
The Royal Rose Premium Ampoule (100ml) uses rose-derived actives - including rose extract, rose water, and potentially rose cell culture extract - for their antioxidant, anti-inflammatory, and skin-brightening properties. Rose is one of the more thoroughly researched floral actives in skincare, with established effects on redness reduction, skin barrier support, and mild brightening from the rosehip-related fraction.
The 100ml size and "Premium" designation position this as a daily-use luxury ampoule rather than a concentrated spot treatment. Rose-based formulas are among the most broadly compatible actives in Korean skincare - they suit all skin types, including sensitive, and have minimal conflict with other actives in the routine. This makes the Royal Rose Ampoule a practical foundation ampoule for people who do not want to manage complex active combinations.
Hyaluronic Vita Toning Ampoule Mask
The Hyaluronic Vita Toning Ampoule Mask is the only mask format in this ampoule collection. It bridges the ampoule category and the sheet mask category by delivering hyaluronic acid and vitamin actives in ampoule concentration via a sheet mask format. The "toning" descriptor refers to a brightening and evening effect from the vitamin component alongside the hyaluronic hydration.
This mask works well as a weekly intensive treatment to supplement daily ampoule use - applying the mask after the daily ampoule step adds a concentrated second layer of the same active family for a treatment-level session. Alternatively, it functions as a standalone weekly hydration and brightening mask independent of the rest of the ampoule collection.
Melanone X Ampoule Cleanser: Brightening from Step One
The Melanone X Ampoule Cleanser (150ml) extends the brightening Melanone X approach to the cleansing step. Including brightening actives in a cleanser maximizes the daily exposure to the formula - even a rinse-off product deposits trace active ingredients during the cleanse window. The 150ml format supports daily morning and evening use over approximately 2-3 months.
For people building a full brightening-focused MEDIPEEL routine, pairing the Melanone X Cleanser with the Melanone X Vitamin Ampoule and Mela Plus Tox Ampoule creates consistent multi-step brightening treatment. Each product hits the brightening mechanism at a different stage of the routine - cleansing removes surface pigmentation debris, the ampoule delivers active treatment, and consistent sun protection with SPF prevents new marks from forming.
Celltox Dermage Ampoule 100ml: Cellular Repair
The Celltox Dermage Ampoule (100ml) is MEDIPEEL's large-format cellular detox formula. The "Dermage" component of the name refers to skin damage repair - addressing accumulated cellular damage from UV exposure, pollution, and oxidative stress. At 100ml, the bottle provides extensive daily use. The formula uses actives that neutralize cellular-level oxidative damage and support the skin's self-repair mechanisms.
This ampoule is particularly relevant for urban skin with chronic pollution exposure, skin that has experienced significant sun damage over years, or skin showing premature aging from environmental factors rather than intrinsic aging. It sits at the prevention and repair end of the spectrum - most effective used before significant damage accumulates, but also useful for skin already showing early oxidative aging signs.
How to Choose from 27+ MEDIPEEL Ampoules
The fastest path through MEDIPEEL's ampoule range is matching primary concern to ampoule family. For pigmentation and brightening: Melanone X Vitamin Ampoule or Mela Plus Tox Ampoule. For anti-aging firming and wrinkle reduction: Peptitox Ampoules or Redracto Collagen Ampoule. For cellular detox and pollution damage: Celltox Dermage Ampoule or Leaftox Ampoule. For general luxury hydration and antioxidant support: Royal Rose Premium Ampoule. For intensive hydration treatment: Hyaluronic Vita Toning Ampoule Mask.
When multiple concerns apply - brightening and anti-aging, for example - choose the concern that is most visible or most important to address first. After 8 weeks of consistent use with one ampoule, you can assess whether to continue or add a second ampoule at a different routine step (morning for one concern, evening for another). Starting with two active ampoules simultaneously is less useful than committing to one and giving it a full treatment cycle to produce results.
FAQ
Frequently asked questions
FAQ
Frequently asked questions
How does the MEDIPEEL Peptitox Ampoule reduce wrinkles without injections?
The Peptitox Ampoule uses Argireline-type peptides (acetyl hexapeptide) that partially inhibit neurotransmitter signals at facial muscle junctions when applied topically. This creates a mild muscle-relaxing effect on expression-related lines around the eyes and forehead. The effect is significantly weaker than injectable botulinum toxin and requires consistent daily use to maintain. It is best described as a subtle softening of dynamic wrinkles over time rather than a dramatic line-elimination.
Do I need to wear SPF when using the Melanone X Vitamin Ampoule?
Yes. Brightening ampoules work to fade existing pigmentation, but UV exposure during treatment generates new melanin that counteracts the fading. Daily SPF 30+ in the morning is essential for brightening products to produce visible results. Skipping SPF while using the Melanone X Vitamin Ampoule significantly slows or negates the pigmentation improvement the formula is working to provide.
What is the difference between the Mela Plus Tox Ampoule 30ml and 35ml versions?
The 35ml is the standard retail size and typically the higher-concentration version of the two. The 30ml may reflect a different concentration level or a variant formula with adjusted active ratios. For most users, the 35ml is the primary choice. The 30ml may be more appropriate as a starting concentration for first-time users of brightening-tox formulas, or it may simply reflect different product generation batches. Check the specific product descriptions for active ingredient concentrations when both are available.
Is the Royal Rose Premium Ampoule safe for sensitive skin?
Generally yes. Rose extract is one of the gentler active ingredients in Korean skincare. The anti-inflammatory properties of rose actives actually benefit reactive skin by reducing irritation triggers. The main risk is fragrance sensitivity from the rose scent - if you are fragrance-reactive, check whether the formula uses synthetic rose fragrance or only natural rose extract, as the latter is less likely to trigger contact reactions than synthetic versions.
Is the Celltox Dermage Ampoule specifically for people living in polluted cities?
It is particularly relevant for urban skin with daily pollution exposure, but it is also useful for anyone with sun-damaged or environmentally stressed skin regardless of city living. The cellular detox mechanism neutralizes oxidative damage from multiple sources - UV, particulates, ozone, and other environmental stressors. City dwellers with heavy pollution exposure will see the most acute benefit, but the antioxidant and repair actives are broadly applicable.
Can oily skin use the Redracto Collagen Ampoule without adding shine?
Yes. Collagen peptide ampoules are typically water-based or light gel textures without the heavy emollient base of collagen creams. The Redracto Collagen Ampoule's 70ml format and serum-category positioning suggest a light, fast-absorbing texture suitable for oily and combination skin. The lacto ferment component also has mild sebum-regulating properties that work favorably for oily skin types.
How often should I use the Hyaluronic Vita Toning Ampoule Mask?
1-3 times per week. The ampoule mask format provides a more concentrated application than daily leave-on ampoule use, so daily masking is unnecessary and wasteful. For a maintenance hydration schedule, once weekly is sufficient. For intensive treatment during dry seasons or pre-event skin prep, up to 3 times weekly is appropriate. Leave the mask on for 15-20 minutes and pat remaining essence into skin without rinsing.
What is the difference between the Leaftox Ampoule and the Celltox Dermage Ampoule?
The Leaftox Ampoule uses plant-based (leaf) detox actives - botanical extracts known for their cellular detoxifying properties. It is a lighter, botanically-focused formula. The Celltox Dermage Ampoule at 100ml uses cellular-level damage repair actives and is positioned more specifically at oxidative skin damage from UV and pollution. The Celltox is the more intensive formula; the Leaftox is the gentler botanical entry point to MEDIPEEL's detox ampoule family.
Can the Melanone X Ampoule Cleanser work on pigmentation by itself?
As a standalone product, the cleanser contributes minimally to pigmentation reduction because rinse-off time is too short for significant active ingredient penetration. Its value is as a complementary first step in a brightening routine - daily contact with Melanone X actives across cleansing, ampoule, and SPF steps accumulates more total active exposure than using any single step alone. For visible pigmentation results, pair the cleanser with the Melanone X Vitamin Ampoule and daily SPF.
Are MEDIPEEL ampoules on skinsli.com the same formulas sold in Korea?
Yes. All MEDIPEEL products on skinsli.com are sourced from Korean suppliers and match the Korean domestic market formulas. They carry Korean batch codes and expiry dates. MEDIPEEL is an active Korean brand with a strong domestic retail presence, and skinsli imports through verified direct channels rather than grey-market sources.












