MEDIHEAL Ampoules

MEDIHEAL's ampoule mask collection brings together 20+ sheet masks saturated with concentrated ampoule-level formulas. The range covers anti-aging and lifting (Peptide Lifting Ampoule Mask, EGT Timetox Ampoule Mask), calming and recovery (Madecasoside Derma Ampoule Mask, Tea Tree Ampoule Mask), hydration (The H.P.A. Ampoule Mask, Derma HPA), brightening (Vitamin Derma Ampoule Mask, Derma IPI), the multi-active Derma EGT, and the everyday Easyti Ampoule Mask. An ampoule mask delivers higher concentrations of active ingredients than a standard hydrating sheet mask, making it appropriate for specific treatment goals rather than basic moisture.

  • Concentrated Ampoule Formulas
  • EGT Antioxidant Masks
  • 20+ Masks in Stock
  • Korean Clinical Brand

By Skinsli editorial Updated

Buying guide

MEDIHEAL Ampoule Masks: What Each Active Does and How to Choose

MEDIHEAL's ampoule masks sit at the treatment end of their product range. Unlike basic hydrating sheet masks, ampoule masks saturate the sheet with formulas closer in concentration to leave-on ampoule serums - higher in active ingredients, more targeted in effect, and generally used with a specific skin concern in mind. The 20+ products in this collection span anti-aging peptide and EGT actives, cica-based calming, HPA hydration, vitamin brightening, tea tree acne treatment, and general daily use formulas.

Peptide Lifting Ampoule Mask: Anti-Aging and Firmness

The Peptide Lifting Ampoule Mask uses signal peptides that target the skin's collagen and elastin synthesis pathways. Applied in a sheet mask format, the occlusive seal of the wet sheet maximizes peptide contact time with the skin surface. Peptides as a category have a strong evidence base for influencing skin firmness, reducing the appearance of fine lines, and improving skin elasticity over consistent use.

This mask suits mature skin or skin showing early firmness loss. For best anti-aging results, use 2-3 times per week as part of an evening routine. The peptide actives work synergistically with a retinol step used on alternate nights, though do not apply both on the same evening as the mask contains enough active ingredients for one treatment window.

EGT Timetox Ampoule Mask: Antioxidant Defense

The EGT Timetox Ampoule Mask uses Ergothioneine (EGT) - the same antioxidant active found in the Derma line - in a standard sheet mask format rather than the Derma positioning. Ergothioneine is a mitochondrial protectant antioxidant that protects against free radical damage from UV exposure and environmental pollution. The "Timetox" in the name refers to reversing time-related oxidative damage.

This mask works particularly well as a morning-before-events mask or after heavy sun or pollution exposure. EGT's antioxidant capacity is stronger than vitamin C per unit weight and more stable over time, making the Timetox mask a meaningful protective treatment rather than a cosmetic placebo. Use 2-3 times per week to maintain consistent antioxidant support.

The H.P.A. Ampoule Mask: Intensive Hydration

The H.P.A. Ampoule Mask focuses on hyaluronic acid-adjacent hydration actives to deliver intensive moisture replenishment. The HPA formula addresses dehydrated, tight skin and is the most versatile mask in the collection because hydration concerns apply to all skin types at some point. Unlike the more active-specific masks, the HPA version is appropriate for all skin types as a hydration boost.

The Derma HPA variant (also in this collection) uses the same core hydration approach within the Derma positioning, with slightly adjusted formulation for post-treatment or sensitive skin contexts. For most users, the standard H.P.A. Ampoule Mask covers hydration needs; the Derma version is worth switching to specifically during post-treatment recovery.

Madecasoside Derma Ampoule Mask: Calming and Recovery

The Madecasoside Derma Ampoule Mask combines the calming properties of madecasoside (Centella Asiatica active) with an ampoule-level concentration in the Derma format. This mask is specifically positioned for skin in a recovery or calming phase - post-acne marks, post-procedure redness, or reactive skin that needs anti-inflammatory treatment delivered at higher-than-standard concentration.

The Derma positioning means this mask shares formulation positioning with the Derma Base Sunscreen and Derma modeling packs - it is designed with dermatologically sensitive contexts in mind. For skin that tolerates all skincare well without sensitivity, the standard Tea Tree or H.P.A. masks may be more practical. For reactive or treated skin, the Madecasoside Derma Ampoule is the most appropriate soothing choice in the collection.

Vitamin Derma Ampoule Mask: Brightening Treatment

The Vitamin Derma Ampoule Mask uses vitamin C derivatives and brightening actives in the Derma ampoule format. It targets dull skin, early hyperpigmentation, and uneven skin tone. The Derma ampoule concentration makes it a stronger brightening treatment than a standard vitamin sheet mask. Apply 2-3 times per week in the evening, and use SPF daily while using brightening actives regularly.

The vitamin mask pairs naturally with the Vitamide Blemish Pad from the pads collection - the pad provides daily brightening maintenance through the toner step, while the ampoule mask delivers a more concentrated weekly treatment dose. This combination addresses brightening at two intensity levels without ingredient conflict.

Tea Tree Ampoule Mask: Acne and Oil Control

The Tea Tree Ampoule Mask delivers tea tree extract at ampoule concentration for treating active breakouts, calming inflamed acne, and controlling surface bacteria that contribute to congestion. The sheet mask format keeps the tea tree ampoule in direct contact with all affected skin areas simultaneously - more effective for widespread breakouts than spot treatments that cover only one area at a time.

This mask works well on evenings after exfoliation steps that can cause temporary surface bacteria exposure, after sweaty workouts, or during breakout clusters. It is not a daily mask but a targeted treatment mask used when skin is actively breaking out or when you want to prevent a breakout from spreading. Leave on for 15-20 minutes rather than overnight.

The Easyti Ampoule Mask: General Daily Use

The Easyti Ampoule Mask is MEDIHEAL's everyday-format ampoule mask, positioned for regular use without a specific treatment concern driving the choice. It delivers a broad active combination for hydration, light brightening, and general skin condition support. For people new to ampoule masks or who want a versatile option that does not require matching to a specific concern, the Easyti is the least restrictive choice in the collection.

It serves well as a base rotation mask that you use when skin feels generally good but you want a treatment step, alternating with more specific active masks on days when a particular concern needs addressing. At its general-use positioning, it is also the safest for those with unpredictable or variable skin reactions.

Derma EGT and IPI Masks: The Derma Ampoule Range

The Derma EGT and Derma IPI masks expand the antioxidant and brightening Derma line beyond the HPA and Madecasoside variants already covered. The Derma EGT delivers ergothioneine in the Derma formulation context - appropriate for post-treatment or sensitive skin that needs antioxidant protection without the intensity of the standard Timetox version. The Derma IPI delivers illuminating peptide actives in the calmer Derma base.

For a comprehensive Derma rotation, these four Derma Ampoule Masks (EGT, HPA, IPI, Madecasoside) can be rotated through the week to deliver different active focuses while staying within the Derma brand's post-treatment-appropriate formulation standards. This rotation approach addresses antioxidant, hydration, brightening, and calming needs within a single consistent mask product family.

FAQ

Frequently asked questions

  • An ampoule mask saturates the sheet with a formula closer in active ingredient concentration to a leave-on ampoule serum rather than a basic hydrating essence. Standard sheet masks primarily deliver hydration and surface moisture. Ampoule masks deliver targeted actives - peptides, EGT, vitamin derivatives, tea tree - at concentrations intended to produce visible improvement in a specific skin concern over consistent use. The format is the same, but the active load is higher.

  • Yes. Ergothioneine is a potent antioxidant that neutralizes reactive oxygen species generated by UV exposure, pollution particulates, and environmental oxidative stress. The EGT Timetox mask delivers a concentrated dose of this protection. For urban skin that experiences daily pollution exposure, using this mask 2-3 times per week provides meaningful cumulative antioxidant support alongside a daily antioxidant serum.

  • 2-3 times per week is the standard recommendation for treatment masks. For the Peptide Lifting Mask, consistent twice-weekly use over 8-12 weeks produces visible improvement in skin firmness and fine-line appearance. Using it more often does not accelerate results proportionally. On non-mask evenings, a peptide serum or the Collagen Filling Pad provides continuous peptide input between mask sessions.

  • Yes. The HPA mask's focus on hydration makes it broadly appropriate across all skin types, including oily and combination skin, which often have dehydrated underlying layers despite surface oil. Dehydrated oily skin is a common condition where the skin produces extra sebum to compensate for moisture loss. The HPA mask addresses the dehydration without adding heavy occlusive oils that would worsen surface oiliness.

  • Yes. The Tea Tree Ampoule Mask is designed for active breakouts. Apply it on evenings when skin is breaking out, leave on for 15-20 minutes, and do not press or rub the affected areas when removing. The tea tree ampoule concentration reduces surface bacteria and calms inflammation around active lesions. Avoid using it on open or ruptured pimples, which should be left to heal without a sheet mask pressed over them.

  • Yes, but follow immediately with SPF. Vitamin C derivatives and brightening actives are photosensitizing - skin is more vulnerable to UV-induced pigmentation after using them. If you use the Vitamin Derma Mask in the morning, apply SPF 30+ before going outside. Evening use is generally preferable as it allows the brightening actives to work overnight and removes the need for immediate SPF follow-up in your routine.

  • The Madecasoside Derma mask is better for post-acne recovery - reducing redness, calming remaining inflammation, and supporting barrier recovery after breakouts clear. The Tea Tree Ampoule Mask is better during active breakouts for anti-bacterial and inflammation control. The two masks address different phases: Tea Tree during the breakout, Madecasoside Derma in recovery. Using the Madecasoside mask while acne is still active is safe but less targeted for active lesions than the Tea Tree version.

  • Yes. The Easyti Ampoule Mask is the most general-use formula in the collection, which makes it the least risky entry point. It does not contain high concentrations of a single potent active that could cause reaction in first-time users. It gives you a baseline experience of the ampoule mask format and MEDIHEAL's sheet quality before you move to more targeted formulas like the Peptide Lifting or Tea Tree versions.

  • Yes. All MEDIHEAL products on skinsli.com are sourced from Korean suppliers and match the formulas sold in Korean pharmacies and skincare stores. They carry Korean batch codes and expiry dates. MEDIHEAL is one of Korea's largest sheet mask brands with extensive domestic retail, and skinsli imports directly from the Korean market rather than through grey-market distributors.

  • Both deliver Ergothioneine as the primary antioxidant active. The Derma EGT is formulated within the Derma line, which targets post-treatment or sensitive skin and uses a base designed to minimize irritation during skin recovery. The standard EGT Timetox Ampoule Mask is formulated for general daily use with a higher-active-concentration approach. For skin undergoing treatments or with compromised barrier, use the Derma EGT. For stable skin that wants maximum antioxidant delivery, use the Timetox version.