Isntree Serums
Isntree builds its serum line around single active ingredients dosed at clinical-leaning percentages rather than long fragranced blends. The lineup spans a Hyper series (Niacinamide 20, Retinol EX 1.0, Vitamin C 23, Acid4 AHA BHA PHA LHA 30) alongside gentler daily options like Green Tea Fresh Serum and Ultra-Low Molecular Hyaluronic Acid Serum, plus a Hyaluronic Acid Fresh Sun Serum for daytime hydration under SPF. Shoppers here are usually targeting a specific concern (texture, brightening, hydration, barrier support) rather than browsing generally, so each product page states its percentage and pH-relevant actives up front.
By Skinsli editorial Updated
Buying guide
How to choose an Isntree serum
Isntree names most of its serums after the active ingredient and its concentration, so the product name is usually the fastest way to find the right one. This guide breaks down what each line does and how to slot a serum into a routine without stacking conflicting actives.
Hyper Niacinamide 20 Serum: texture and tone
This is the brightening and pore-texture option in the range, formulated at a 20% niacinamide level. It works for uneven tone, visible pores, and general dullness. Niacinamide can pill under thick moisturizers, so apply it to slightly damp skin and let it absorb before layering anything heavier.
Hyper Retinol EX 1.0 Serum: retinol for experienced users
At a 1.0% concentration this is meant for skin already used to retinoids, not a first-time retinol. Start at two or three nights a week, always at night, and follow with a barrier-supporting moisturizer. Skip it on nights you use the Acid4 exfoliating serum to avoid over-thinning the skin.
Hyper Vitamin C 23 Serum: brightening and antioxidant support
A high-percentage vitamin C serum aimed at dullness and uneven tone, best used in the morning under sunscreen where the antioxidant protection has the most benefit. Vitamin C at this strength can feel tingly on sensitised skin, so patch test before working it into a daily routine.
Hyper Acid4 AHA BHA PHA LHA 30 Serum: multi-acid exfoliation
This serum blends four acid types at a combined strength for chemical exfoliation, targeting texture, congestion, and buildup without a separate physical scrub. Because it combines multiple acid categories, use it on alternating nights rather than daily, and pair it with sunscreen the following morning.
The hyaluronic acid serums: daily hydration base
The Ultra-Low Molecular Hyaluronic Acid Serum uses smaller HA molecules that sit closer to the surface for quick plumping, and works well as a first hydrating step after toner. It layers safely under the Hyper actives and doesn't compete with them the way two active-heavy serums would.
Hyaluronic Acid Fresh Sun Serum: hydration with SPF
This one is a daytime hybrid, combining hydration with sun protection so it can replace a separate sunscreen step for people who want fewer products in the morning. It's a lighter finish than a standalone sunscreen, which suits normal-to-dry skin more than very oily skin.
Green Tea Fresh Serum: calming, low-irritation option
The gentlest serum in the lineup, built around green tea extract for calming and light antioxidant support. It's a reasonable entry point for anyone who reacts to actives elsewhere in the range, or a soothing layer to insert after a retinol or acid night.
Layering the range without overlap
A simple split: hydration serum (Ultra-Low Molecular HA or Green Tea) every day, one active serum (Niacinamide, Vitamin C, Retinol, or Acid4) at a time depending on the current concern, and the Sun Serum only in the morning if it's replacing sunscreen. Retinol and the acid blend should not be used on the same night.
Sizes and how the line is sold
Most of the range ships in 20ml or 50ml bottles depending on the concentration; the higher-strength Hyper actives tend to come in the smaller 20ml size since less is needed per use. Stock on any single serum can rotate, so check the live count on each product page before committing to a routine built around it.
FAQ
Frequently asked questions
FAQ
Frequently asked questions
Which Isntree serum is the strongest active?
The Hyper Retinol EX 1.0 Serum is the most potent single active in the lineup at a 1.0% concentration, followed by the Hyper Acid4 AHA BHA PHA LHA 30 Serum, which combines four acid types. Both are meant for skin already comfortable with actives rather than a first routine.
Can I use the Niacinamide 20 Serum and Vitamin C 23 Serum together?
Yes, though most people get better results splitting them: Vitamin C in the morning for antioxidant protection under sunscreen, and Niacinamide in the evening for texture and tone. Using both in one application can work for tolerant skin, but starting split reduces the chance of irritation.
Is the Hyper Retinol EX 1.0 Serum suitable for a first retinol?
It's on the higher end for a first retinol. Someone new to retinoids is usually better off building tolerance with a lower-percentage product first, then moving up to this one, rather than starting at 1.0% and risking irritation.
What's the difference between the two hyaluronic acid serums?
The Ultra-Low Molecular Hyaluronic Acid Serum is a straightforward daily hydrator using smaller HA molecules for fast surface plumping. The Hyaluronic Acid Fresh Sun Serum adds SPF on top of hydration, so it's built for daytime use as a combined moisture-and-sun-protection step rather than a pure hydrating serum.
Does the Hyaluronic Acid Fresh Sun Serum replace sunscreen?
It can for people who want a lighter, all-in-one morning step, since it combines hydration with SPF. Anyone spending extended time outdoors or wanting a higher, more precise SPF should still layer a dedicated sunscreen on top.
Is the Green Tea Fresh Serum suitable for sensitive skin?
It's the calmest formula in the range, built around green tea extract without the high-percentage actives found in the Hyper line, which makes it a reasonable starting point for reactive or sensitised skin, or a soothing layer to use the night after an active treatment.