Histolab Cream

Histolab's cream range covers the main facial moisturizer categories: barrier-repair centella formulas, azulene-based calming creams, a brightening whiteness cream, and a dedicated hydrating cream for water-deficit skin. Several products come in both 80ml consumer sizes and 500ml professional-use jars, which is useful for estheticians or heavy daily users who want bulk supply.

  • Korean clinical skincare
  • 20+ creams in stock
  • Pro 500ml sizes available
  • Centella + Azulene formulas

By Skinsli editorial Updated

Buying guide

Histolab Creams: Centella, Azulene, Brightening and Hydrating Formulas

Histolab is a South Korean clinical skincare brand that produces professional-grade formulas used in esthetic practices as well as retail-sized products for home use. The cream range covers several distinct skin concerns: barrier support through centella, calming through azulene, brightening through whitening actives, and deep hydration through humectant-rich formulas. With 20+ creams in stock, the collection has enough variety that most skin types can find a targeted option rather than settling for a general moisturizer.

Centella Green Cream and Centella Red Cream

Histolab offers two centella-based creams that take different angles on barrier support. The Centella Green Cream (50g) is the lighter of the two, formulated for sensitive skin that needs soothing without heaviness. The Centella Red Cream (80g) is richer and targets more compromised or dry-sensitive skin. Both contain centella asiatica extract, which is well-documented for reducing transepidermal water loss and calming reactive skin.

The green/red naming refers to the product's color and associated skin focus, not flavor. The green cream suits everyday use on sensitive combination skin; the red cream is better suited as a repair cream for periods when the skin barrier is visibly stressed, such as after retinol use, professional peels, or environmental damage.

Azulene DNA Cream

Azulene is a blue compound derived from chamomile that has anti-inflammatory and calming properties. The Histolab Azulene DNA Cream is available in both 80ml and 500ml sizes, suggesting it is used professionally as well as at home. The formula is designed for reactive, couperose-prone, or post-procedure skin that needs both calming and film-forming protection.

Azulene works differently from centella: centella is more about barrier lipid support, while azulene acts more directly on visible redness and inflammation. If your skin tends to flush or stays red after cleansing, the Azulene DNA Cream is a more targeted option than the centella formulas.

Whiteness Cream for Brightening

The Histolab Whiteness Cream (80ml) addresses uneven skin tone and dullness. In Korean skincare, "whitening" or "whiteness" products focus on brightening and reducing hyperpigmentation rather than changing natural skin tone. The active ingredients typically target melanin synthesis to reduce dark spots and post-acne marks.

This cream works best as a PM moisturizer since brightening actives in a cream base are usually most effective overnight when the skin is in repair mode. It can be used as a standalone moisturizer for normal or combination skin types looking to address pigmentation alongside daily hydration.

Watermax Hydrating Cream

The Watermax Hydrating Cream (500ml) is a high-volume hydration-focused formula, available in the 500ml professional size. It is designed for dehydrated skin, which is characterized by tightness, fine dehydration lines, and dullness that resolves with good hydration rather than barrier oils. The formula prioritizes humectants over heavy emollients, making it lighter than a traditional rich cream while still providing significant moisture.

The 500ml size makes it practical for estheticians to use during facial treatments or for clients who use a cream twice daily and want a supply that lasts several months without reordering frequently.

Delta Active Cream

The Delta Active Cream comes in both 80ml and 500ml. The "Delta Active" name in Histolab's line typically indicates an active-targeting formula with a multi-functional approach, addressing multiple concerns simultaneously. The professional 500ml size suggests it is used as a treatment cream in clinical settings, applied after procedures to accelerate recovery and hydration.

For home use, the 80ml size is the practical choice. Given its professional-grade positioning, it is best used as a final step in a treatment-focused routine rather than as a basic daily moisturizer.

Ceracles Water Cream

The Ceracles Water Cream is a lightweight gel-cream that focuses on barrier ceramide support combined with water-based hydration. Ceramides are lipid molecules that make up a significant part of the skin barrier, and ceramide-depleted skin tends to feel rough, tight, and reactive. A water cream format delivers the ceramides in a texture that suits combination-to-oily skin better than a rich cream formulation.

This is a good choice for oily skin types who still want barrier support without the heaviness of a traditional cream. It also works well under sunscreen and makeup since the water-cream texture does not leave residue.

Premium Timeless Cream for Anti-Aging

The Premium Timeless Cream (80g) is Histolab's dedicated anti-aging moisturizer. It is a richer formula than the water-based or gel-type creams in the range, suited for mature skin or anyone dealing with dryness and loss of firmness. The "timeless" positioning indicates a focus on skin-firming actives and sustained moisture rather than quick surface hydration.

Best used at night or as a daytime cream in dry climates. On combination skin, it may be heavier than needed in the T-zone; apply it only to drier zones (cheeks, perimeter of the face) if shine is a concern.

Professional 500ml Sizes

Several Histolab creams come in 500ml professional jars (Azulene DNA Cream, Delta Active Cream, Watermax Hydrating Cream). These large-format products are typically used in esthetic clinics and spas where the same product is applied to multiple clients or used in high quantities per session. For individual buyers, the 500ml format makes sense if you use a cream every morning and evening and want a cost-effective bulk supply.

The 500ml jars ship with airtight lids and are designed for dispensing with a spatula to maintain hygiene. If ordering for home use, store in a cool place away from direct sunlight to maximize shelf life of the open product.

Picking the Right Histolab Cream for Your Skin

The simplest way to choose is by primary concern. For sensitive and reactive skin, start with either the Centella Green Cream (lighter) or Centella Red Cream (richer). For redness and couperose, the Azulene DNA Cream is the targeted choice. For dehydrated skin that is not primarily sensitive, the Watermax Hydrating Cream or Ceracles Water Cream are better fits. For dark spots and uneven tone, the Whiteness Cream is the only dedicated brightening option in the range.

If you are dealing with post-procedure recovery or mature skin that needs active support alongside moisture, the Delta Active Cream or Premium Timeless Cream are the higher-intervention choices. Most of these creams can be layered after a serum and before SPF in the morning, or used as the final step at night.

FAQ

Frequently asked questions

  • The Centella Green Cream (50g) is lighter and suits sensitive combination skin for daily use. The Centella Red Cream (80g) is richer and is better for dry-sensitive or compromised skin that needs more substantial barrier repair. Both contain centella asiatica for soothing, but the red cream provides more occlusive protection.

  • Yes. Azulene has well-established anti-inflammatory properties and is specifically useful for reducing visible redness and calming reactive or couperose-prone skin. The Azulene DNA Cream is one of the most targeted products in the Histolab range for persistent facial redness.

  • No. In Korean skincare, whitening or whiteness products are brightening formulas that target hyperpigmentation and dullness. They work by inhibiting melanin synthesis to reduce dark spots and post-acne marks. They do not alter natural skin tone or have a bleaching effect.

  • Yes, though they are primarily designed for professional esthetic use. For home users who use a cream twice daily, a 500ml jar can last 6-12 months depending on application amount. Store with a spatula rather than fingers to keep the product hygienic, and keep the lid tightly closed.

  • Yes. The Ceracles Water Cream is a gel-cream format, which is lighter than traditional creams and does not leave a heavy residue. It provides ceramide barrier support without adding excess sebum-like richness. It works well under sunscreen and makeup for oily skin types who still need barrier hydration.

  • It is formulated for mature or dry skin that is experiencing loss of firmness and sustained dryness. It is a richer formula and may feel heavy on oily or combination skin in the T-zone. For combination skin, applying it only to drier areas like the cheeks and jaw is a good approach.

  • The Delta Active Cream is a multi-active treatment cream best used in a targeted skincare routine, such as after professional procedures, during active treatment phases, or when using other actives like retinoids or exfoliating acids that need barrier support. Its professional-grade positioning makes it more suitable for treatment use than as a basic daily moisturizer.

  • Histolab is a South Korean brand that bridges both markets. The brand produces products used in esthetic clinics (especially the 500ml professional sizes) as well as consumer-sized products (80-80g/ml) for daily home use. The formulas are clinically oriented, meaning they are built around specific actives for specific concerns rather than general-purpose appeal.

  • It depends on the cause of dryness. If your skin is dehydrated (lacks water, feels tight after cleansing, shows surface dehydration lines), the Watermax Hydrating Cream with its humectant focus is the better match. If your skin is dry and reactive or sensitized with barrier compromise, the Centella Red Cream addresses both the dryness and the barrier damage more directly.

  • There are 20+ Histolab creams available on Skinsli, including both consumer (80-80g/ml) and professional (500ml) sizes across several formulas: Ceracles Water Cream, Whiteness Cream, Centella Green and Red Creams, Azulene DNA Cream, Delta Active Cream, Premium Timeless Cream, and Watermax Hydrating Cream.